개똥쑥 (진피쑥) 에 대한 연구자료가 놀랍네요
산애들애 연구진도 개똥쑥에 대한 연구자료에 주목하구있답니다
개똥쑥 문의 = 1566-8466
개똥쑥의 다른 이름은 황화호[黃花蒿: 본초강목(本草綱目)], 취호[臭蒿, 초호:草蒿: 일화자제가본초(日華子諸家本草)], 향사초[香絲草, 주병초:酒餠草: 광주식물지(廣州植物誌)], 마뇨호(馬尿蒿, 고호:苦蒿: 귀주민간방약집(貴州民間方藥集)], 황향호[黃香蒿, 황호:黃蒿, 야통호:野筒蒿: 강소식약지(江蘇植藥誌)], 계슬엽[鷄虱葉: 강서초약(江西草藥)], 추호[秋蒿, 향고초:香苦草, 야고초:野苦草: 상해상용중초약(上海常用中草藥)], Artemisia annua L.[학명], Annual Wormwood[영국명], Annual Wormwood[미국명], 쿠소닌징[クソニンジン(糞人参=분인삼=똥인삼), 호소바닌징:ホソバニンジン: 일본명], 잔잎쑥, 초고, 향고, 개땅쑥, 개똥쑥, 계피쑥, 비쑥 등으로 부른다.
[채취]
가을에 베어서 그대로 햇볕에 말리거나 잘라서 토막으로 하여 햇볕에 말린다.
미국 워싱턴대학 연구팀(researchers at the University of Washington)은 암을 죽이는 능력이 기존 약보다 1200배 가까이 되는 약초에 대해 보고(the new compound is more than 1,200 times more specific in killing certain kinds of cancer cells than currently available drugs)했다.연구팀은 '암 저널(Cancer Letters)'을 통해 '개똥쑥(Artemisia annua L)'에 대해 "암 세포만을 선택적으로 공격하도록 처리한 후 백혈병 세포에 투여했더니 폭탄처럼 암 세포를 죽이는 것으로 조사됐다"며 "전립선암과 유방암 치료에도 쓰일 수 있는지 연구를 진행 중"이라고 밝혔다.
개똥쑥에 대한 미국의 원문 내용은 아래과 같다.
[Scientists develop new cancer-killing compound from salad plantOct. 13, 2008/Science/Health and Medicine
Researchers at the University of Washington have updated a traditional Chinese medicine to create a compound that is more than 1,200 times more specific in killing certain kinds of cancer cells than currently available drugs, heralding the possibility of a more effective chemotherapy drug with minimal side effects. The new compound puts a novel twist on the common anti-malarial drug artemisinin, which is derived from the sweet wormwood plant (Artemisia annua L). Sweet wormwood has been used in herbal Chinese medicine for at least 2,000 years, and is eaten in salads in some Asian countries. The scientists attached a chemical homing device to artemisinin that targets the drug selectively to cancer cells, sparing healthy cells. The results were published online Oct. 5 in the journal Cancer Letters. "The compound is like a special agent planting a bomb inside the cell," said Tomikazu Sasaki, chemistry professor at UW and senior author of the study. In the study, the UW researchers tested their artemisinin-based compound on human leukemia cells. It was highly selective at killing the cancer cells. The researchers also have preliminary results showing that the compound is similarly selective and effective for human breast and prostate cancer cells, and that it effectively and safely kills breast cancer in rats, Sasaki said. Cancer drug designers are faced with the unique challenge that cancer cells develop from our own normal cells, meaning that most ways to poison cancer cells also kill healthy cells. Most available chemotherapies are very toxic, destroying one normal cell for every five to 10 cancer cells killed, Sasaki said. This is why chemotherapy's side effects are so devastating, he said. "Side effects are a major limitation to current chemotherapies," Sasaki said. "Some patients even die from them." The compound Sasaki and his colleagues developed kills 12,000 cancer cells for every healthy cell, meaning it could be turned into a drug with minimal side effects. A cancer drug with low side effects would be more effective than currently available drugs, since it could be safely taken in higher amounts. The artemisinin compound takes advantage of cancer cell's high iron levels. Artemisinin is highly toxic in the presence of iron, but harmless otherwise. Cancer cells need a lot of iron to maintain the rapid division necessary for tumor growth. Since too much free-floating iron is toxic, when cells need iron they construct a special protein signal on their surfaces. The body's machinery then delivers iron, shielded with a protein package, to these signals proteins. The cell then swallows this bundle of iron and proteins. Artemisinin alone is fairly effective at killing cancer cells. It kills approximately 100 cancer cells for every healthy cell, about ten times better than current chemotherapies. To improve those odds, the researchers added a small chemical tag to artemisinin that sticks to the "iron needed here" protein signal. The cancer cell, unaware of the toxic compound lurking on its surface, waits for the protein machinery to deliver iron molecules and engulfs everything -- iron, proteins and toxic compound. Once inside the cell, the iron reacts with artemisinin to release poisonous molecules called free radicals. When enough of these free radicals accumulate, the cell dies. "The compound is like a little bomb-carrying monkey riding on the back of a Trojan horse," said Henry Lai, UW bioengineering professor and co-author of the study. The compound is so selective for cancer cells partly due to their rapid multiplication, which requires high amounts of iron, and partly because cancer cells are not as good as healthy cells at cleaning up free-floating iron. "Cancer cells get sloppy at maintaining free iron, so they are more sensitive to artemisinin," Sasaki said. Cancer cells are already under significant stress from their high iron contents and other imbalances, Sasaki said. Artemisinin tips them over the edge. The compound's modus operandi also means it should be general for almost any cancer, the researchers said. "Most currently available drugs are targeted to specific cancers," Lai said. "This compound works on a general property of cancer cells, their high iron content." The compound is currently being licensed by the University of Washington to Artemisia Biomedical Inc., a company Lai, Sasaki and Narendra Singh, UW associate professor of bioengineering, founded in Newcastle, Wash. for development and commercialization. Human trials are at least several years away. Artemisinin is readily available, Sasaki said, and he hopes their compound can eventually be cheaply manufactured to help cancer patients in developing countries. Other authors of the study are Steve Oh, UW medical student; Byung Ju Kim, UW chemistry instructor; and Singh. The Washington Technology Center and the Witmer Foundation provided funding for the study. ]
(동아대 대체의학 외래교수 전동명)
개똥쑥에 대해서 북한에서 펴낸 <약초의 성분과 이용>에서는 이렇게 기록하고 있다.[잔잎숙(Artemisia annua L.)다른 이름: 개똥쑥, 초고, 향고식물: 높이 약 1m 되는 한해살이풀이다. 잎은 2~3번 깃겹잎이다. 쪽잎은 버들잎 모양이고 가늘다. 늦은 여름철에 풀색을 띤 노란색 꽃이 핀다. 각지의 들판, 산기슭에서 자란다.성분: 뿌리에는 사포닌(거품지수 1:100)이 있다. 전초에 0.04~0.64%의 정유, 탄닌질, 수지, 쓴맛물질, 약간의 비타민 K, 플라보노이드가 있다.정유의 테르펜 부분의 12~24%는 α-피넨, 4.2~9.8%는 캄펜, 2~6.5%는β-피넨, 1~3%는 사비넨, 0.3~13%는 α-테르피넨, 1.5~12.8%는 1, 8-시네올(유탈리프톨), 0.6~2.9%sms P-시몰, 5.7~51%는 아르테미시아케톤, 11.4~37%는 캄포르, 이소아르테미시아케톤이다.다른 자료에 의하면 정유에는 카디넨, 카리로필렌, 보르네올-ι-β-아르테미시아알코올, 아세프산, 헥세날, ι-d 피넨, 쿠미놀, 펜타코잔이 있다고 한다.
<>전화주시면 보내 드립니다 <강화 개똥쑥>=1566-8466
|
q4.jpg 
